The top 10 most profitable industries in a given year can vary based on various factors such as market conditions, economic trends, and changes in consumer behavior. However, based on recent trends and projections, the following industries are often considered among the most profitable in 2021:

1. Technology industry: Including software development, IT services, and hardware manufacturing.
2. Healthcare and pharmaceuticals: Including pharmaceutical manufacturing, biotechnology, and healthcare services.
3. E-commerce and online retail: With the rise in online shopping and changing consumer behavior.
4. Financial services: Including banking, insurance, and investment firms.
5. Renewable energy: As companies focus on sustainability and clean energy solutions.
6. Gaming and entertainment: Including video games, streaming services, and online media.
7. Mobile app development: With the increased reliance on smartphone apps and digital services.
8. Artificial Intelligence and Machine Learning: As businesses integrate AI and ML technologies to enhance operations and decision-making.
9. Electric vehicles and transportation: With the growing demand for eco-friendly modes of transportation.
10. Real estate and property development: As the housing market remains strong and commercial real estate adapts to changing needs.

It’s important to note that profitability can vary significantly within each industry, and success depends on various factors such as market positioning, innovation, and effective management.